Abstract
The effect of short and long term administration of ciclosporin (CYA) on renal functions and morphological changes were studied using Sprague Dawley rats. Serum concentrations of blood urea nitrogen and urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) were increased when a high dose of CYA was administrated for a short term or a low dose of CYA for a long term. Main morphological features of the kidneys were as follows, tubular vacuolization, necrosis, and microcalcification with the dose of 25 mg/kg/day for 10 weeks or 100 mg/kg/day for 1 week, but renal lesions such as glomerulopathy, interstitial fibrosis, interstitial mononuclear cell infiltrates and arteriolopathy were appeared with the dose of 5 and 10 mg/kg/day for 24 weeks. These nephrotoxicity induced by CYA was irreversible and may be caused by disturbance of microcirculaton of nephron.
