Abstract
Lobenzarit exerts various kind of modulating effect on lymphocyte and significantly therapeutic activity in rheumatoid arthritis. However it is not known yet whether lobenzarit affects some paticular mechanism on pathogenesis of rheumatoid arthritis by correcting some abnormality. A long term clinical study was performed to assess the effectiveness of lobenzarit taken over extended periods by patients with rheumatoid arthritis. Consequently, it was shown that lobenzarit has favorable characteristics as a second line drug, but usually affords greater clinical benefit when used as a first line drug in the early stage of rheumatoid arthritis.
