Abstract
The clinical response to ciclosporin (CYA) in 8 patients with complete Behçet's disease was analyzed. The frequency of ocular attacks became fewer after the initiation of CYA treatment (10mg/kg/day), however, it increased again 80-100 weeks later with reduction of CYA dosage. Extra-ocular symptoms (oral aphthous ulcer, skin eruption and genital ulcer) had been in remission throughout the treatment period for 150 weeks. Several adverse events, such as nephrotoxicity, hypertrichosis, gingival hypertrophy or neurologic lesions were noted in the majority of the patients, which necessiated the reduction of the drug dosage. Hence, the initial dosage will be lessened below 8 mg/kg/day and great care must be exercised in close monitoring of the serious side effects of CYA.
