Abstract
We treated the noncancerous and cancerous patients with severe infections using the COG-78 and antibiotics, and determined the absolute numbers of neutrophils, lymphocytes, lymphocyte subpopulations and serum concentrations of immunoglobulins. (1) In the noncancerous patients, the numbers of neutrophils and the N/L ratios decreased to normal ranges, in contrast, in the cancerous patients, these parameters increased throughout the test periods. (2) The OKT4/T8 ratios of the noncancerous patients were always higher than those of the cancerous patients. (3) In both noncancerous and cancerous patients, the numbers of lymphocytes decreased at the sixth day after the start of treatment but the numbers of active T cells increased throughout the test periods. (4) The cancerous patients who manifested poor prognosis showed markedly increased numbers of neutrophils and high N/L ratios. (5) In the noncancerous patients, the serum concentrations of IgG increased after administration of COG-78, on the contrary, in the cancerous patients, the concentrations of IgG decreased.
