Abstract
Recurrent rheumatoid nodules from the patient with rheumatoid arthritis were investigated. Immunohistochemical analysis of the early rheumatoid nodules suggested that immune responses among CD4 positive T cells and HLA-DR positive mesenchymal cells might be involved in the development of the nodules. Furthermore, interleukin-1 activity were detected in the culture supernatant of the nodules. The role of cytokines in the rheumatoid nodules should be further investigated.
