Abstract
When trinitrophenylated hepatocytes and lipopolysaccharide are intravenously injected into trinitrophenylated liver protein sensitized guinea pigs, most of the guinea pigs die of massive hepatic cell necrosis within 24 hours of LPS injection. Using this experimental model, we studied the changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue of guinea pigs with experimentally-induced massive hepatic cell necrosis. As a result, both the levels of LTs and PGs in the liver tissue increased. These results suggest that the arachidonic acid metabolites may play an important role in the induction of liver cell injury.
