Abstract
The regulation of peripheral blood and uterine NK cell is very important for the achievement and maintenance of successful pregnancy. Natural cytotoxicity receptor (NCR) including NKp46 is unique receptor on NK cell that has functions for NK cell cytotoxicity and cytokines production. We have firstly shown the lower expression of NKp46 on NK cells in non-pregnant women with recurrent pregnancy loss (RPL) and implantation failure. Besides, that lower expression of NKp46 on NK cell was detected in pregnant women with a history of RPL, pregnancy women with pregnancy induced hypertension and women with pelvic endometriosis. So, the lower expression of NKp46 on NK cells may be a common phenomenon in reproductive failure and cause abnormal cytokines production by NK cells. In this review, the lower expression of NKp46 on NK cell for various situation of reproductive failure was shown and discussed.
