2019 Volume 34 Pages 9-16
Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.
However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far, many HDP model animals have been exploited and accelerated the HDP research. In the research of HDP, many Japanese researchers have occupied important parts in both in vitro and in vivo experiments, in addition to clinical discoveries. In this review, we explain about the relations between HDP and sFlt-1, and then introduce mainly two kinds of model mice of HDP by our groups.
