Abstract
A 33-year-old female patient with initialy complaints of asthma for about ten years had acute, rapidly progressive generalized vasculitis. Her symptoms included fever, chest pain, wheezing, abdominal pain, diarrhea, mononeuritis multiplex and skin necrosis on the extremities.
Laboratory examinations demonstrated eosinophilia, serum IgE 7200 IU/ml, and positive antiENA. Endoscopy showed ulcerative colitis endoscopy and histopathologic study of a skin specimen showed vasculitis with eosinophylic infiltration.
The addition of cycrophosphamide to high dose prednisone was followed by gradual and complete remission of clinical and laboratory abnormalities.
