Abstract
The mechanism of the joint destruction in rapidly destructive coxopathy (RDC) was studied by analyzing the bone resorption factors in joint liquid.
The joint liquid revealed bone resorbing activities. Prostaglandins (PGs) were found to play a partial role in joint destruction. The values of interleukin-1β (IL -1β) of the joint liquid were higher than those with osteoarthritis. When the joint liquid was tested for proteolytic activity by zymography performed with SDS/polyacrylamide containing gelatin two gelatin-degrading activities with molecular weights of 95KDa and 57KDa were observed. Cells cultured from synovia obtained at surgery revealed a gelatinolytic activity with a molecular weight of 95KDa in the primary culture. PGs, IL-1β and gelatinase seem to act synergetically as promotion factors in the rapid destruction of the hip joint in RDC.
