Abstract
There are few reports concerning the function of metabolites produced by gut microbiota. Polyamines are one of the most important metabolites produced by gut microbiota affecting the health and disease of the host. Polyamines have many functions, such as the maturation and maintenance of intestinal mucosal barrier, anti-inflammatory actions, antimutagenicity, and autophagy. In our recent study, longevity in mice was promoted by the administration of Bifidobacterium animalis subsp. lactis LKM512, which upregurates gut bacterial polyamine production. This paper reviews the promotion of longevity following LKM512 administration and introduces the metabolomics analysis using capillary electrophoresis with time-of-flight mass spectrometry (CE-TOF MS) for clarification of metabolite profiles in the gut lumen.
