Regulatory mechanism of cytokines and arachidonic acid metabolites produced by Kupffer cells

Abstract

Kupffer cells produced cytokines including interleukin 1 (IL1) and tumor necrosis factor (TNF), chemical mediator in cluding platelet activating factor (PAF) and arachidonic acid metabolites including prostaglandins (PGs) and leukotrienes (LTs). When Kupffer cells treated with PGs, production of IL1 and TNF was significantly reduced. But, the production of cytokines increased by Kupffer cells treated with LTs. Furthermore, TNF and IFN-γ increased PGs production by Kupffer cells. But, IFN-α and IFN-β decreased PGs production. These results was suggested that networks in Kupffer cells may be regulated by cytokine cascade and arachidonic acid cascade.