Abstract
Chromosomal translocations involving 3q27 were found with non-Hodgkin's lymphomas of diffuse large cell type. The low frequency of bone marrow infiltration and high incidence of extranodal involvement were suggested. There have been the conflicting results concerning the prognosis of the patients with the BCL6 rearrangements. A 36 year old male patient with gastric lymphoma was described. He received subtotal gastrectomy and adjuvant chemotherapy. Although he could achieve complete remission, he relapsed at the cervical lymph node swelling eight years later. The 3q27 translocations are unique in that this locus translocate to not only the immunoglobulin genes (IGH, IGK, IGL) but also to non-random variable translocation partners. This case indicates the significance of der (3) than der (2) for tumor cells to gain growth advantage.
