Abstract
It is reported that serum testosterone exerts various effects on the human body with prostate cancer. One of the testosterone actions is prostate cancer activity, and another testosterone action affects the physical condition of prostate cancer patients, such as body mass index (BMI) and bone mineral density (BMD). It is reported that free testosterone has more biochemical activity than total testosterone, thus we examined the relationship between the serum testosterone (total T and free T) level and Gleason score (GS), clinical stage and PSA level of the untreated prostate cancer patients. We also examined the relation between serum testosterone and physical condition, such as BMI, BAP, NTX and BMD. No significant relation was seen between T and GS, clinical stage, BAP, NTX and BMD, however PSA values and serum T level showed an inverse association. This result indicates that the prostate cancer that grows under low testosterone level may have higher malignancy. Another interesting result was the patients with high BMI showed a lower testosterone level. This result may indicate that the prostate cancer patients with higher BMI may have a disadvantage of toxicity of hormone treatment that may increase the risk of cardiovascular events. Statistical analysis showed some differing results between T and free T in our study. We suggest both T and free T should be measured in order to investigate the role of testosterone. Upon elucidation of this role, the prospects of further examination will increase in the future.
