硫酸マグネシウム投与前後でイオン化マグネシウム濃度を測定した小児気管支喘息大発作の2症例

矢川 綾子; 中村 俊紀; 宮沢 篤生; 阿部 祥英; 石川 良子; 北條 菜穂; 神谷 太郎; 今井 孝成; 板橋 家頭夫

doi:10.14930/jsma.72.674

Case Report

IONIZED MAGNESIUM LEVELS IN 2 CASES OF SEVERE ASTHMA ATTACK BEFORE AND AFTER TREATMENT WITH INTRAVENOUS MAGNESIUM SULFATE

Ayako YAGAWA, Toshinori NAKAMURA, Tokuo MIYAZAWA, Yoshifusa ABE, Ryoko ISHIKAWA, Naho HOJO, Taro KAMIYA, Takanori IMAI, Kazuo ITAHASHI

Author information

Ayako YAGAWA
Department of Pediatrics, Showa University School of Medicine
Toshinori NAKAMURA
Department of Pediatrics, Showa University School of Medicine
Tokuo MIYAZAWA
Department of Pediatrics, Showa University School of Medicine
Yoshifusa ABE
Department of Pediatrics, Showa University School of Medicine
Ryoko ISHIKAWA
Department of Pediatrics, Showa University School of Medicine
Naho HOJO
Department of Pediatrics, Showa University School of Medicine
Taro KAMIYA
Department of Pediatrics, Showa University School of Medicine
Takanori IMAI
Department of Pediatrics, Showa University School of Medicine
Kazuo ITAHASHI
Department of Pediatrics, Showa University School of Medicine

Keywords: childhood asthma, respiratory failure, MgSO₄, ionized Mg

JOURNAL FREE ACCESS

2012 Volume 72 Issue 6 Pages 674-679

DOI https://doi.org/10.14930/jsma.72.674

Details

Abstract

We successfully treated 2 cases of severe asthma attack that showed response to initial treatment by intravenous infusion of magnesium sulfate (MgSO₄). Total serum magnesium (tMg) and ionized magnesium (iMg) and ionized calcium (iCa) were measured before and after 1 hour administration of MgSO₄. Compared to before the MgSO₄ administration, both cases showed an increase in tMg and iMg and a decrease in the iCa/iMg rate. We propose that the changes in the iCa/iMg rate may serve as an index of the effect of intravenous magnesium. To clarify the efficacy and safety of intravenous MgSO4 in the treatment of asthma, many cases should be studied.

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