Abstract
The authors has accidentally had an opportunity to observe a severe case of sepsis accompanied by distinct leucopenia and anemia. The case did not show any cardiac symptoms, and both of the liver and spleen were not palpable. The only symptom was high remitting fever with perspiration. In serveral instances, Gram-positive diplococci were detected from blood as well as from the exudate collected from right pleural cavity. An intensive chemotherapy and blood transfusion were applied for this case. Sulfonamide and penicillin were also administered. Especially in the case of penicillin, a total of 80, 000, 000 units were administered. Two injections of 1, 500, 000 units of water soluble penicillin were given daily in the beginning, and later they were substituted by penicillin in oil. Despite the above intensive treatment, no antifebrile effects were noticed. Just at that moment, aureomycin was made available for the treatment, which was administered as follows.
For the first two days, two capsules every three hours totalling sixteen capsules or 4 g daily, for the next three days, two capsules every four hours totalling twelve capsules or 3 g daily, and for the next two days, two capsules every six hours totalling eight capsules or 2 g daily were given. Starting from the following day, one capsule every six horns totalling four capsules or 1 g daily were given. Thus a total of 100 capsules or 25 g of aureomycin were administered. The fever dropped 9 days after the initiation to the 37°C level of the treatment, and recovered normal temperature after 13 days. The blood sedimentation rate was 21 within 1 hour after 24 days since the initiation of the treatment. The diplococci had disappeared during the course of penicillin treatment. As side reaction of the drug, nausea was noticed on the third day, which was not sufficiently distinct to discontinue the treatment.
Thus, as stated above, aureomycin demonstrated a striking effectiveness to improve all clinical symptoms on a case, for which penicillin failed to show any effectiveness inspite of the administration of a known sufficient dose in the past literatures. The present paper reports the details of the treatment.
