Abstract
In the present paper, experiments on the general actions and absorption of vitamin. B1, thiamine-propyl-disulfide and thiamine-allyl-disulfide (abridged hereunder as B1, TPD and TAD) are reported.
When mice were injected intravenously with 3.5 mg of TAD or 3 mg of TPD, they immediately become fatal. However, with 1 mg of TAD or TPD, there were, generally, . no remarkable actions found. No remarkable changes in the temperature of rabbits were recognized with a moderate amount of TAD or with TPD.
In the Shioya's 3 rd Method, the amplitude of the isolated toad heart was not changed by these drugs at their lower concentrations. They also did not cause any changes. in the number of pulsation, amplitude or in the amount of infusion liquid of the isolated guinea .pig heart at their lower concentrations. Although the application of these drugs inn a small amount or in a moderate amount did not show remarkable changes in the blood pressure or in the respiration of rabbits, a large amount (10mg/kg) of TAD or TPD caused a moderate lowering of blood pressure and stimulation of respiration. They also cause aa transient contraction of the blood vessel in the posterior extremity of toad but this action was observed somewhat stronger in the case of TPD. TAD or TPD did not demonstrate inhibitory actions on the vascular actions of adrenalin. No changes in the intestinal movement of the isolated intestine of rabbit were caused by TAD or by TPD. A slight tendency of erythropenia and leukocytosis in the hemogram when a large amount of TAD or TPD was applied. In the hemogram, a transient decrease in the percentage of lymphocytes and an increase in the percentage of pseudo-eosinophiles with lobulated nucleus were recognized. As to the absorption of B1, TAD and TPD, the absorption of TAD and TPD from the stomach and the large intestine was found evidently more rapid than B1.
