Abstract
Aiming at detailed investigations of the influences exercised by various substances on the absorption of histamine in the large intestine, the author selected bile components (cholic acid, taurocholic acid, cholesterin), rabbit bile, urea, thiourea, vitamin B1 hydro-ciloride, thiamine-propyl-disulfide and various surface active agents (Hyren, Emulgen 106, Tween 20, Span 20) as combined substances. In the case with surface active agents, duodenal infusions were also conducted in order to make comparative studies with the influences exer-cised on the absorption in the small intestine. Furthermore, in the cases when calcium preparations were administered in combination, the calcium content of the serum and peritoneal fluid was estimated in order to investigate the correlationships with the absorption of calcium, which had already been elucidated by Hitomoto and Kato.
Pathological and histological investigations on the liver were also made, thereby the influences of histamine and other substances given in combination on the liver were observed.
As the result of the present experiment, the following conclusions were drawn.
The absorption of histamine in the large intestine is promoted by rabbit bile, taurochglic acid and cholic acid when they are given in combination with histamine, but the absorption promoting action of cholesterin is found to be slight. The absorption promoting effect of urea and thiourea, especially of the former, is also remarkably evident. Among the surface active agents, the absorption promoting action exercised by Hyren and Emulgen is especially remarkable. When histamine alone is administered, the pathological histologicgal findings of the liver is mild, but when administered in combination with rabbit bile, taurocholic acid, urea or with thiourea, the findings in the liver become evident. When calcium chloride is further combined in this case, the disturbances in the liver is alleviated.
