Abstract
Giving injections of philopon to fertilized hen's eggs, the authors conducted histopathological investigations on the cerebral tissue of chick embryo during the incubation. The following results were thus obtained.
(1) In the leptomeninx congested blood vessels were generally observed. It was accompanied by hemorrhage in the early stage, and by cell infiltrations in the late stage of incubation.
(2) In the brain, congestion of the parenchymal blood vessels was observed in the whole area. In the late stage of incubation, it demonstrated expanding picture. Further, in the cases high concentration injections were given, the picture was accompanied by hemorrhage. Cell infiltration was recognized in the cases with the injection of 1 mg. and with 5 mg.
(3) Coarseness of the tissue was recognized in the late stage of incubation in the cases with low concentration, but was recognized since early stage in the cases with high concentration.
(4) Demyelination foci were observed in the cases with all concentrations employed in the present experiment except with 10 mg in the late stage of incubation. Further, slight necrosis-like or necrotic pictures were noted in the cases with 5 mg.
(5) As changes in the nerve cells, diffuse homogeneous changes or serious changes were observed since 12 th day of incubation, though the degree was generally slight.
(6) The progress of neuronophagia was in parallel with that of the degeneration of nerve cells in the cases with all concentrations employed in the present experiment since 12 th day of incubation though slight in degree.
(7) Proliferation of glia cells was recognized in the late stage of incubation in the cases with low concentration, and since early satge in the cases with high concentration.
(8) Particularly pathological fat deposite was not observed in the nerve cells, myelin sheath or in the glia cells. However, presumably reciprocal fat degeneration was recognized in the cases with 1 mg on 15 th day of incubation.
