Abstract
In the present paper, comparisons were made between the results of the studies onn the so-called experimental mumps and those on the natural epidemic mumps. Further, from this angle of observation, discussions were made on the host-parasite broblem in the mumps virus infection. Previously, the authors conducted and reported the studies on the human experimental mumps induced by the Showa B strain of virus isolated by the authors.
Basing upon the clinical findings, hemogram, antibody formation, etc., cases were divided into 4 Types as follows:
Type I····Cases showing clinical findings, hematologic findings and antibody formation
Type II····Cases of which incubation period was not noted or was very short
Type III····Cases in which only antibody formation was noted
Type IV ····Cases which showed no reaction
The authors, on the other hand, investigated an epidemic of mumps which broke out in a local primary school in Sizuoka Prefecture, and learned that these cases can be divided into 4 Types according to clinical findings, antibody formation, etc. Discussions were made, e from various angles, on these two kinds of mumps.
For the experimental mumps, amniotic fluid virus possessing the hemagglutination titre of 1280 was canulated into Stensen's duct by Johnson and Goodpasture's technique.
In the epidemic mumps, the causative virus was wild, and was not so-called egg adapted virus. Further, in the latter case, the infecting dosis and the actual infection site were not known.
When compared with the wild virus, amniotic virus was presumed to possess more dissociation or some changes in the character. Hence, some altered host response for this.s was considered.
Discussions were also made on the fact that clinical manifestations of mumps in the experimental case were accompanied first by parotide swelling, while, in the epidemic mumps, such relation was not clear. In the experimental mumps, parotitis was restricted on the canulated side, while, in the epidemic mumps, parotitis was unilateral or bilateral.
In the epidemic mumps, cases belonging to Type II can not be detected. Furthermore, Type II has not yet been referred to in any experimental mumps in the past. The presence of Type III suggested the presence of the cases tiding over the disease without symptoms not necessarily possessing detectable antibody before infection.
Similary, as to the Type IV, it suggested the presence of thee cases which tide over the disease without detectable complement fixing antibody or reaction.
Making discussions on each Type, the present paper referred to the truthfulness of the authors' experimental mumps and to various problems which can not be made clear merely by the observations on the epidemic mumps.
