Abstract
1) The authors experienced a case which demonstrate shock-like symptoms induced by the application of penicillin vaginal suppository and penicillin intradermal reaction. Since the symptoms became manifest during continuous application of suppository, the authors noticed the great cautiousnegs even in the application of suppository similarly to the injection therapy.
2) Since 1953, penicillin treatmhnts were given to 1, 484 cases in the authors' Deparment. Allergic symptoms were observed in 16 case (1.07), and serious shock symptoms were recongized in 2 cases (0.13) . Among the 16 reative cases, 12 cases (75%) were caused by injections.
