Abstract
The effects of a series of anti-tumor substances on ova in their early stage of development or having strong power of fission, ovum cells, spermatovum, or pregnant ova, and especially on the sex organs, their functions, and the reproductive functions of rats have been studied. The following results were obtained.
(1) Nitromin and Carzinophilin could control the sex cycles. Large dose of Azan could change the sex cycles in few cases.
(2) The minimum effective dose of Nitromin, Azan and Carzinophilin for the controll of sex cycles was 3.7 mg/kg, 100-200 mg/kg, and 838.9 u/kg respectively.
(3) The controling effect of sex cycles was transient, and they were recovered to the normal soon after the administrations were suspended.
(4) The body weight decreased remarkably when Nitromin or Carzinophilin was administered. On the other hand, it was rather increased when Azan was administered. The restoration of weight-loss nearly coincided with the recovery of the sex cycles. The changes of the body weight were related to the dose administered.
(5) Microscopic examinations of ovary and uterus of these rats were suggestive of the lack of estrus.
