Abstract
The effects of anti-tumor substances on the pregnant ovum and foetus have been studied. The following results were obtained.
(1) Abortion may easily occur in the earlier the stage of pregnancy by administration of anti-tumor substances, or the more they were administered. Abortion occurred in 100 % in the early stage by administration of Nitromin with minimum effective dosage of 2.4 mg/kg. In the middle stage, the abortion occurred in 42.9% with 3.8 mg/kg, while 6.7% of it occurred in the last stage with the same dosage. The minimum safe dosage of Nitromin to bring the normal delivery was 21.7 mg/kg.
As for Azan, abortion was caused in 86.7% when it was administered in the early stae with the minimum effective dosage of 24.1 mg/kg: 66.7 % in the middle stage with 22.4 mg/kg: and none of it occurred in the last stage. The minimum safe dosage of Azan to bring the normal delivery was 256.3 mg/kg.
In the early stage of pregnancy the administration of 4, 878 u/kg Carzinophilin caused abortion in 42.8 %, while in the middle stage 40 % was caused with dosage of 6, 000u/kg, and in the last stage none of it occurred. The minimal safe dosage of Carzinophilin to bring the normal delivery was 10, 256.4 u/kg. No deformities were found on the foetus delivered normally.
(2) The necrosis, bleedings, and infiltrations of connective tissue in placenta remaining in the uterus were seen in cases of abortion. Atrophy of corpus luteum was seen in the ovary.
(3) The cause of abortion seems to be influences of anti-tumor substances on placenta, foetus and ovary of the maternal animal.
(4) No deformities were found.
