Abstract
Nicotine was used for the histopathological study concerning the toxic disturbance the central nervous system.
Subcutaneous injections of nicotine were given to mice daily for a period of 30 days. The animals were then sacrificed and their brains were studied histopathologically.
1) The nerve cells demonstrated swelling, vacuolar formation, homogenization, liquefaction, edematous changes, localized“Ausfall”, vocuolization, swelling of nuclei, homogenization and disappearance of nude.
2) The majority of the degenerative changes of nerve cells are anoxemic changes induced by the toxic action of nicotine, or are combined with hydropic encroachment directly Teaching the cells from the surrounding tissues.
3) Nicotine acts upon the brain as a histotoxic hypoxydase ; it reaches the vessels and induces a primary indirect changes, while on the other hand, it induces a secondary direct change.
4) Edema is the most remarkable among the primary indirect changes. Hemodynamic edma plays the main role, and disturbance of the blood-brain barrier is extremely mild, and PAS-positive substances can hardly be detected.
5) Edematous uncertainty is the morphological figure of the edematous changes of each element of the nervous tissue developing from the rarefaction in the gray substance, and in the white substance they show transitional figures to demelinized changes by the abundant medullated nerve fibers.
