Abstract
Pharmacological effects of TTFD on respiratory and circulatory systems as well as on smooth muscle organs of rabbits and toads have alreaey been reported. Further studies were undertaken on several other organs and the results obtained are summarized in the following :
TTFD was found to have pharmacological effects similar to these of vitamin B1 though there was quantitative difference between the two. Toxicity of TTFD was much smaller than vitamin B1 and it seemed to be retained in the body for a longer period of time.
In view of the changes observed on the blood pressure and respiration of rabbits administered of TTFD, it was concluded that this preparation is not adequate for intracisternal administration.
It has, moreover, no appreciable influence on the activities of adrenaline or acetylcholine.
