Abstract
Rabbits administered of nicotine either by a single injection of 10 mg/kg or by a daily dose of 1 mg/kg repeated for 10 days were determined of the total quantity of vitamin B1 as well as its blood and urine concentration. In either case of the two kinds of nicotine administration, there was a remarkable decrease of vitamin B1 on the first day after completion of the injection. This tendency was especially strong on those which had received 1 mg/kg repeatedly for 10 days and they also required a longer period in restoring their normal condition.
Moderate degenerative changes were observed on the liver and the kidney of the rabbits received a daily dose of 1 mg/kg nicotine for 10 days.
