INFLUENCE OF NAPHTHALIN ON THE LINGUAL GLANDS OF RABBIT
1959 Volume 19 Issue 6 Pages 564-575
Details
1959 Volume 19 Issue 6 Pages 564-575
1. In the present experiment, naphthalin was administered in a dose of 1.0 mg /kg body weight on rabbits, which then were put into 4 groups of Acute Groups I (naphthalin dissolved in olive oil and fed on vitamin C deficient diet), Acute Group II (same as abovt but fed on usual diet), Chronic Group I (naphthalin powder and fed on vitamin C deficient diet) and Chronic Group II (same as above but fed on usual diet) .
Then, comparisons of lingual glands (Ebner gland and Weber gland) as well as pathohistological examinations of the rabbits of above mentioned 4 groups were carried out.
2. On comparison of acute and chronic groups, changes observed on the acute groups were stronger than those of chronic groups.
3. On comparison of groups I and II, in either case of acute or chronic groups, the former presented stronger changes. Namely, the toxic effect of naphthalin is considered to be alleviated by vitamin C.
4. As for Ebner gland, changes such as irregular arrangement, cloudy swelling and destruction of the grandular epithelia, cloudy swelling of the epithelia of the secretory duct, hyperemia of the interstitial tissue, cellular infiltration, crook, divergence, disconnection and disappearance of the reticular fibers of the basal membrane etc were observed in the acute groups I and II. Further, some other changes, though mild in intensity, were also observed in group I.
5. As for Weber gland, likewise, changes such as irregular arrangement, dissociation, swelling and liquefaction of the grandular epithelia, dilatation of the secretory duct, hyperemia of the interstitial tissue, cellular infiltration, decrease in argentaffinity, swelling, crook, divergence, disconnection and disappearance of the reticulum fibers etc were observed in both acute groups I and II. Further, some other changes were observed in group I.
6. Various degenerative changes observed on the lingual glands are considered to be due to the tissue toxic secondary influence of naphthalin, namely, they correspond to the secondary direct type changes in which hypoxidosis plays an important role in their development.
