Abstract
1. The acute toxic effect of Furfural in rabbits is stronger than Hydroxymethyl furfural.
2. Furfural administration is free from developing leucocytosis which can be observed at the initial stage of Hydroxymethyl furfural administration. The same can be said when Furfural is administered on splenectomized rabbits.
3. Administration of Furfural causes an evident decrease in the count of erythrocytes. Further, there is no remarkable difference between normal rabbits and splenectomized rabbits.
4. Histopathological changes of the cirrhosis of the liver was observed on the normal and splenectomized rabbits successively administered of Furfural for a period of 6 months.
In short, the presence or absence of spleen was found to have nothing to do with the toxic effect of furfural, especially, the hepatic disturbance due to the feeding of Furfural.
