Abstract
Pantothenic acid, thioctic acid and orotic acid which are considered to have a physiological activity as coenzyme were administered on the patients of arterial sclerosis for a period of 4 weeks for the investigation of their decholesterolizing effect. Quantitative determination of the total cholesterol, morever, was done by the use of Zak-Kitamura's modification and the cold deprotenization method of this author's device. The results obtained were as follows:
The rate of the lowering of total cholesterol of the 42 cases received pantothenic acid was -12.5%. Seven cases received 45 mg of thiotic acid showed the rate of lowering -2.2%, while 16 cases received 60 mg showed the rate of -11.4 %. In the case of orotic acid, the 14 cases received 600 mg showed the rate of lowering -6.7%. Namely, some decholesterolizing effect was observed in all cases of the coenzymes examined in the present study.
