Abstract
Listeriosis, an infectious disease in common among human and animal, develops sepsis in infants and young animals and abortion or encephalitis in adult human and animals. Especially, encephalitis is its main symptom. As a prophylactic measure for this infection, studies have been made on various kinds of killed vaccine, but none of them were found to be of complete satisfaction. On confirmation of the development of listerial encephalitis without fail by the route of infection discovered by Asahi et al, this author employed this method of challenge for the assessment of the prophylactic effect of various kinds of killed vaccine. The results showed that all the killed vaccine such as heat killed vaccine, formalinzed, chrome-alum adsorped, alcohol killed or the brain emulsion of the infected mice inactivated by formalin and culture filtrate all failed to show sufficient immunity,
It has been said that killed vaccine has no prophylactic effect and this author could confirm this on listerial encephalitis. Thus, it can be said that it is impossible to inhibit the development of listerial encephalitis by killed vaccine.
