Abstract
In the present experiment, diethyl-paranitrophenyl-thiophosphate in a varying dose of 2, 4, 8, 12 and 16 mg/kg was injected subcutaneously into female rats, and after repeating the injections required, they were mated with normal male rats. Pathological investigations were made on the kidney of the new borns thus obtained (sacrificed on the 3rd adn 7th day after birth) and of the maternal rats, and at the same time, the relationship of the effect of maternal intoxication to the placental cord was investigated.
In summarizing the renal findings of acute groups, they can be said as the acute diffusive glomerulonephritis accompanying the alternative “ Veränderung ” of the tubular epithelium. As for the changes produced in the glomeruli, moreover, the toxic effect is considered to exert direct primary damages on the endothelial cells of the loop.
Consolidative changes observed on chronic groups are the final picture of acute glomerulonephritis and interstitial hydroma is considered to have played the most important role in the production of these fibrotic changes.
Renal disorders of the suckling rats were proved to consist of inflammatory, retrogressiv and growth disturbing changes. The fact that the renal changes of the suckling rats were always milder than those of the mother rats is construed as the expression of the inhibitory influence of the placental cord against the transmission of toxic substances.
