STUDIES ON ANEMIA PRODUCING SUBSTANCE IN THE SERUM
1960 Volume 20 Issue 4 Pages 360-380
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1960 Volume 20 Issue 4 Pages 360-380
It was in earlier papers shown that anemia producing substance of the human serum was merely found out in the patients of hypoplastic anemia, nephritis and cancer.
In this paper, it was described that this substance was also demonstrated in the serum of normal healthy persons. The numbers of erythrocytes and hemoglobin were markedly decreased after repeated injection of normal serum with ascorbic acid showed a tendency to prevent the decrease of erythrocytes and hemoglobin after injection in the rabbits. The numbers of reticulocytes, leucocytes and platelets were unchanged before and after injection of normal serum. Repeated injection of serum to rabbits produced hypoplastic bone marrow, but injection of ascorbic acid treated serum to rabbits were not caused hypoplastic bone marrow. And the correlation between anemia producing substance and globulin substances obtained from 10-fold redistilled water diluted plasma by acetic acid precipitation at pH 5.9-6.1.
