Abstract
1. In the present experiment rabbits received the subcutaneous injection of diethyl-paranitropheny-thiophosphate in different doses of 4mg, 8mg and 12mg/kg body weight twice per week. Rabbits were classified into several groups by the difference in the dose administered, died or survived and further by the number of injections repeated for the comparison of the pathomorphological changes produced in relation to the concentration of the injection with emphasis on the ligual gland (Ebner gland) .
2. In both groups of died and survived, regressive changes of the glandular epithelial cells and the epithelial cells of the secretory duct became gradually severe following the increase in the number of injections repeated and the dose use. With the acticulum fibers of the basal membrane too, there was a slight enhancement in the findings such as crook. divergence, disconnection, disappearance etc.
3. Various retrogressive changes observed on the lingual gland in the present experiment are considered to be the result of tissue intoxicative influence dur to the hypoxydose caused by the administration of parathion. As for the mode of action of these toxic substances, they are considered to exert secondary immediate type action.
