Abstract
1. The author has introduced a newly devised procedure to cure various depressive states administering neuroleptics and psychotonics simultaneously, testified its effectiveness and discussedd the signification.
2. One hundred and forty cases were assigned to this study from those patients who received a complete course of this treatment under continuous and prudent observation. The results were as follows: improved 138 cases (98.5%), among them markedly improved 100 (71.4%), moderately improved 38 cases (27.1%) . Only 2 cases (1.5%) did not respond favorably.
3. Above mentioned super effects are presumably to be attributed to the fact that on this occasion by the combined administration of two kinds of agents which have apparently opposite action, undesirable side-effects are offset reciprocally, nevertheless favorable effects of the two mutiply each other.
4. The choice of drugs, their combination and dosage were determined in each case considering the etiologic factor and clincal feature at the beginning, but these were readily changed in accordance with the fluctuation of symptoms in the course of treatment.
5. By this method the depressive phase of affective psychosis could be remitted without shifting to manic phase.
6. The combined administration showed much higher ratio of improvement compared with that of single adminstration of so-called antidepresant such as Tofranil and monoamin oxidase inhibitors, and the psychopharmacological ground of this fact was discussed.
7. Though in some cases E. S. T, were applied, the numbers of application were very few, and in such cases the memory disturbances caused by E. S. T. which might often aggravate the hypochondric attitude of patients were recovered rapidly due to the action of psychotonics.
8. The psycherapeutic factors inevitably involved in the method were taken into full consideration.
