Abstract
Rabbits received the subcutaneous injection of Sodiumglucuronate (GNa) or Glucuronolactone (GL) for the observation of the influence of this injection on the bloodsugar value and the concentration of plasma K, Na and inorganic P. Further, investigations were made on the changes produced in the electrolytes at the time of the administration of Glucose, Adrenaline and KCI. Stated in the following are the results obtained thereof:
1. Subcutaneous injection of GNa or GL produces a moderate elevation in the bloodsugar value of rabbits, while K and inorganic P concentrations of plasma show a lowering, but the concentration of Na remains unchanged. Teis injection causes a moderate increase in the K concentration of the heart of mice, but the K concentration of muscles remain unchanged.
2. Administration of GNa or GL exerts an inhibitory influnece on the elevation of the bloodsugar value and the lowering of the concentration of plasmic K in the rabbits received the oral administration of Glucose. Lowering in plasmic P concentration, however, is enhanced by the injection of GL. K concentration of the heart and muscles of the mice received oral administration of Glucose receives no influence by the subcutaneous injection of GNa or GL. Plasmic K concentration of the rabbits received the subcutaneous injection of Adrenaline is lowered and the concentration of inorganic P is lowered temporarily but is restored normal. While, K concentration of the heart of mice received Adrenaline injection shows an elevation. Administration of GNa inhibits the lowering of K concentration in the rabbits and both GNa and GL retard the restoration of P concentration lowered by Adrenaline injection. Elevation in the K concentration of the heart of mice caused by Adrenaline injection is inhibited by the administration of GNa or GL.
3. Intraperitoneal injection of KCl causes an elevation in the plasmic K concentration of rabbits and moderately lowers the concentration of inorganic P. Administration of C Na moderately inhibits this elevation of K concentration but does not influence on the lowering of inorganic P concentration. Elevation in the K concentration of the heart, muscles and the liver of mice received KCl is moderately inhibited by the administration of GL.
In short, Glucuronic acid gives an evident influence on the electrolyte metabolism (especially K) of the rabbit's plasma and the visceral organs of mice.
