Abstract
Hypotensive agents such as Hexamethonium bromide (C6), Tetraethylammonium bromide (TEA), Chlorothiazide (Chit), Hydralazine (Ap), Sodium 5, 5 diethylbarbiturate (Bar), Reserpine (Res) were administered on rabbits by intravenous injection for the observation of their respective influence on the metabolism of serum electrolytes like K, Na, Mg and Ca.
Serum K concentration showed a lowering tendency by the administration of TEA, Chlt, Ap and Bar, while it showed an increase by C6. In the case of the administration of Res, there was a biphasic elevation in a dose of 5 mg/kg and a lowering when the dose was 10 mg/kg.
Na concentration of the serum showed and increasing tendency by the administration of C6, TEA and Res, while it showed a lowering by Chit and the administration of Bar produced no remarkable change. In the case of Ap, there was a temporary mild elevation immediately after administration but it was lowered thereafter.
Serum Ca concentration showed an increasing tendency by the administration of C6, TEA and Chlt, while it was lowered by Ap and Res, but Ca concentration was scarcely influenced by the administration of Bar.
Serum Mg concentration showed a lowering tendency by the admistration of Ap and Res, while by the administration of C6, it showed a lowering tendency after a temporary elevation. In the case of Chit and Bar administration, however, no appreciable influence was recognized on the concentration of serum Mg.
In short, the administration of a hypotensive agent produced a remarkable influence on the metabolism of serum electrolytes. Especially, the changes observed on K was most remarkable being influenced by all the drugs tested in the present study.
