INFLUENCE OF p-METHYLPHENYL HYDRAZINE (MPH) ON THE PERIPHERAL BLOOD VESSEL OF RABBIT

Abstract

The influences of p-methylphenyl hydrazine (MPH), 1-isonicotinyl-2-isopropyl hydrazine (IIH) and isonicotinic acid hydrazine (INH) on the adrenaline- and tyramine-action to the rabbit ear vessel were studied.
1) The effects of tyramine on the rabbit ear blood vessel after pretreatment of MPH or IIH which are potent inhibitors of monoamine oxidase, were potentiated, but after pretreatment of INH which is a potent inhibitor of diamine oxidase, were not altered.
2) The effects of adrenaline on the rabbit ear blood vessel after pretreatment of MPH, IIH or INH were not potentiated.
3) The administration of MPH, IIH or INH to the rabbit ear blood vessel caused dilation.