Abstract
Studies were performed on the pattern of hemolysis and change of fraction of serum protein with the production of erythropoietin in the phenylhydrazine-treated rabbits, and following results were obtained.
1. Hemoglobin concentrations, hematcrit and erythrocyte count showed marked decrease after starting the daily injection of phenylhydrazine and reached to the half level in their value by the fifth day.
Reticulocyte count increased abruptly few days after starting injection.
2. Decrease of albumin and increase of α2- and γ-globulin were seen as the degree of anemia enforced.
3. Efforts were done for obtaining different level of hemoglobin concentration upon exanguination. Increased erythropoietin titer was obtained in 85.7 % of specimens with below 6.5 Gm/dl of hemoglobin concentration. However, elevated erythropoietin was seen in few subjects with those of over 6.5 Gm/dl of hemoglobin.
