Abstract
In the present experiment, naphthalene, which is known as a methemoglobin forming substance, was administerated to rabbits by oral application under two feeding ways of standard and V. C deficient food and by intraperitoneal and subcutaneous injection.
The spleens of these rabbits were then examined histologically and the following results were obtained.
1) In the oral administration group (1.0g/kg), the rabbits fed with V. C deficient food through intragastric infusion for a long term showed edema of capsule, atrophy and rarefaction of follicles, fibrous proliferation, thickening of sinus wall and swelling of sinus endothelium. These changes were more remarkable than those fed with standard food.
In the group fed for a short term under the same condition, these changes were only slight, but a similar relation between both breeding ways was observed.
2) Subcutaneous injection (1.0g/kg) for a long term resulted in, thickening of capsule, atrophy of lymph follicles, peri-and intraf ollicular edema and liquefaction, proliferation of reticulum cells, vacuolization of the nuclei, thickening of sinus wall, and edema and necrosis of red pulp of a marked degree.
3) In the naphthalene poisoning, liquef active necrosis occured from exudation to the surrounding area of peripheral arterioles of pulpa, sinus wall and intrafollicular vessels due to acceleration of permeability resulting from hypoxemia.
