THE EFFECTS OF CYTIDINE DIPHOSPHATE CHOLINE ON THE RECOVERY TIME FROM NITROUS OXIDE-OXYGEN AND HALOTHANE ANESTHESIA

Abstract

This study was performed on 30 surgical patients, 9 to 70 years of age. Thiopental induction was followed by succinylcholine, then endotracheal intubation. Anesthesia was maintained with 0.5 % halothane in nitrous oxide-oxygen of 3: 1.51/min, until skin closure was effected. 10 mg/kg of CDP-choline (cytidine diphosphate choline) was administered intravenously about 10 minutes before skin closure. The criteria for recovery from anesthesia were the appearance of eyelash reflex and response to verbal stimuli. CDP-choline significantly prolonged recovery time from anesthesia, without relation to patient's age and sex, or duration of anesthesia.