Abstract
In surgical patients from 11 to 77 years of age, the effects of inosine on normovolemic hypotension due to general or spinal anesthesia were studied. Of 30 patients under nitrous oxide-oxygen-halothane anesthesia, arterial pressure increased in 22 patients, and decreased in other 8 patients, after a single intravenous injection of 400, 1200 and 2000 mg inosine. Compared with 400 and 1200 mg inosine, 2000 mg inosine caused more frequently blood pressure fall. Infusion of inosine resulted in increase of pulse rate in 19 patients, decrease in 7 patients, and no change in remaining 4 patients. Higher dosages of inosine caused more often a increase of pulse rate. In the majority of patients, onset of effect on blood pressure and pulse rate was within 5 minutes, and their duration was beyond 20 minutes. On plethysmograph, amplitude of pulse wave increased significantly after administration of inosine, except in patients under deep halothane anesthesia, and in elderly patients with arteriosclerosis. On e. c. g., R-R interval was shortened with injection of inosine. On electroencephalogram, no change was observed after infusion of inosine. Effects of inosine on blood pressure and pulse rate were more inconsistent and slight in patients under spinal anesthesia than in patients under general anesthesia. No undesirable side effects were observed.
