Abstract
It is well known facts that tissue mast cells (TMC) contribute to maintain homeostasis by produce, storage and secration of heparin, histamine and serotonine. There has been so many reports discussing relationship between heparin and collagenous fibers, and histamine, serotonine and vascular function.
The auther revieed 442 cases of biopsied portio vaginalis for past three years to detect distribution of TMC in various disease.
All biopsied specimens are divided into the following three classification according to it's histopathological findings;
(A) . erosio portionis (390 cases), (B) . dysplasia (4 cases), (C) . carcinoma (48 cases) . Erosio portionis is also divided inot following four classification and TMC is studied in earch group. Results are follow:
1. Erosio portionis consists of 85% of psedoerosion and 15% of true erosion.
2. The number of TMC/mm2in the so-called normal portio vaginalis is 114.79±65.13 stochastically. On distribution of TMC, there are no TMC in the mucosa but numerous TMC in the submucosal stromal tissue. TMC is frequently observed in the portio vaginalis from thirty to fourty decade.
3. On the number of TMC/mm2in the erosio portionis, there are tendency of incressed in number of TMC compared to normal state like following; 153.18±72.81 in the erosio granulans, 138.30±53.57 in the erosio gladularis, 211.80±84.78 in the erosio papillaris, 161.24±87.08 in the erosio glandularis cystica. TMC is more frequently observed from fourty to fifty decade. On distribution of TMC in the tunica propria, TMC is recognized around fibrosis and erosive glands oftenly.
4. In the portio vaginalis, TMC is appeared in the acute inflammatry state (erosio granulans) and more recognized in subchronic state (erosio papillaris) . On the contrary, TMC is disappeared in the settled stste of inflammation (erosio glandularis) . These facts suggest some defence capacity of TMC for maintaining homeostasis.
5. The number of TMC/mm2in cases of dysplasia is 155.00±48.37, and no TMC is observed in the atypical squamous layer. However there are clumpings of TMC just beneath this layer.
6. The number of TMC/mm2in the connective tissue around carcinoma is 128.50±93.78 but no TMC is seen in cancer nestitrelf.
7. It is still obscure whether TMC has defence capacity against neoplastic proliferation or not.
