Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
CORRELATION BETWEEN RADIOSENSITIVITY OF TRANSPLANTED SOLID TUMOR AND NUTRITIVE CONDITION OF HOST ANIMAL
Katsuhito Ando
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JOURNAL FREE ACCESS

1975 Volume 35 Issue 2 Pages 145-151

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Abstract
Studies on radiosensitivity of the tramsplanted tumor were carried out and following results were obtained
1. Radiosensitivity of the tumor ran parallel to the growth rate.
2. Malnutrition of the host after irradiation made the tumor radiosensitive, probably because sublethally damaged tumor cell did not recover.
3. Mitotic index was well correlated to radiosensitivity and low mitotic index caused by starvation made the tumor cell to recover poorly.
4. DNA synthetic rate measured by means of iodine labeled IUdR was not successful to correlate with mitotic rate, presumably because of the role of thymidine pool size in this experiment.
5. Serum protein level was likely to correlate to the tumor growth, which modified the radiosensitivity.
6. Serum oxygen was difficult to interpret, however might be compensated by erythrocytosis in starved condition.
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