Abstract
In order to investigate the degree and development about the interruption of the blood flow in the lowerextremities, the lower abdominal aorta of the dog was occluded as the experimental model.
To makc the acute cases, abdominal aorta was ligated, and gradual constrictor was used to make subacute and chronic cases.
The results obtained were as follows:
1) In acute cases, the serum CPK level increased gradually and showed a high level for 120 minutes clearly. Comparison of the venous serum CPK level in the upper extremity, and the lower extremity, the later was higher and the difference was clear with the prolongation of occlusive period. Concerning the venous blood gas exchange in the lower extremity, an increase in PVCO2, a decrease in PVO2, and a reduction of PH were recognized. It seemed That a metabolic change had occured.
2) In all cases, there were no significant changes in S-GOT, S-GPT, S-LDH and serum CPK levels.
3) In chronic cases, there were some cases of increase of the serum CPK level in the 2 weeks group, after 3 weeks, however, it returned to normal level.
4) Angiographic observation of collateral circulation showed that the higher of occlusive changes were, the more development of bypass was found.
5) Histologically, fibrous hypertrophy in the intima, inflammatory changes in the ads ventitia around the constricted region, and no change in the media were observed.
6) As a result, by measuring the serum CPK leve and PVO2 in the circulatory obstructive extremity, it seemed to be able to estimate the begining of an acute circulatory deterioration even in a chronic case.
