Abstract
By promtly giving an intravenous injection of 10 ml/kg of H.E.S. to a dog of normovolemia, the auther cross-examined change of blood gas, acid-base balance and circulatory movement. The effect obtained were as follows:
1. The rise of Po2 after the H.E.S. injection was so little, as compared with that in clinical examples, that it was not considered to be satistically much significant.
2. Notwithstanding the insignificant change of Paco2, after the H.E.S. injection, PHa went down significantly, base dificit increased, and metabolic acidosis was found generated.
3. From the viewpoint of falling down of hemoglobin concentration, it seemed that the effect of plasma expander would be preserved at least for 60 minites.
4. After the H.E.S. injection, it was recognized that cardiac output considerably increased, arterio-venous oxygen content conspicously decreased, and accordingly, oxygen consumption diminished remarkably, suggesting some trouble on oxygen utilization in tissues.
It was supposed that this, together with the diluted acidosis, would be one of the reasons of the abovestated metabolic acidosis.
5. With the H.E.S. injection, blood was diluted, hemoglobin concentration was weakened, and hence arterio-venous oxygen content was decreased, but according to the exceeding increase of cardiac output, oxygen availabilty was rather increased.
6. After the H.E.S. injection, physiologycal shunt was increased, but it was not much increase as compared with that of cardiac output.
7. After the H.E.S. injection, a tendency of A-aDo2 decrease was shown, but the change was not much significant.
8. With the H.E.S. injection, mean arterial blood pressure was not changed, but cardiac output was increased and peripheral resistance was decreased.
