Abstract
The activities of glutamate dehydrogenase (EC: 1.4.1.3; GMD) in sera from 57 healthy person and 869 patients suffering from various diseases who had been obtained one or more abnomal results in GOT, GPT, LDH, TTT, ZTT, and CCLF values were investigated.
Conclusions are as follows :
1. Normal range of serum GMD levels is 0-1.4 U/l (average ; 0.4 U/l) .
2. Average level obtained from patients is 3.17U/l. GMD activities obtained from serum hepatitis, alcoholic hepatitis, chronic hepatitis, jaundice, and hemo-dialysis are significantly higher than those from other diseases.
3. The correlation coefficient between levels of GMD and LDH, TTT is generally lower than that between GMD and GOT, GPT in all cases.
4. The fluctuation of activities of GMD in serum is closly coincident with the process of clinical findings in serum hepatitis, but in contrary, in acute hepatitis it is observed many cases that GMD level does not or only little change during the higher elevation of other enzyme activities.
