ABOLISHMENT OF ACUPUNCTURE ANALGESIA BY PARTIAL LESION OF PERIAQUEDUCTUAL CENTRAL GRAY
1979 Volume 39 Issue 4 Pages 397-407
Details
1979 Volume 39 Issue 4 Pages 397-407
Acupuncture stimulation (AS) increased the latency of rats' tail-flick test which estimated as pain threshold. In about 50% of examined animals (N=44), AS incresed pain threshold significantly (p<0.05) . In this connection, animals could be classified into acupuncture effective animals or non-effective animals by above criterion (p<0.05) .
The acupuncture-produced analgesia (APA) were completely abolished by insertion electrode (diameter : 0.5mm) to periaqueductual cental gray (PAG) .
Electrical stimulation of PAG caused analgesia, especially that of ventral PAG around aqueduct caused the profound analgesia. Pain threshold was not changed significantly (p <0.05) by electrode insertion to PAG. Electrical destruction of PAG also abolished the APA and pain threshold was not changed significantly (p<0.05) by destruction of PAG.
After PAG stimulation, APA recovered slightly, however its changes were not significant.
APA were partially abolished by administraion of naloxone (10mg/kg) .
Abolishment of acupuncture analgesia by electrode insertion to PAG was disscused by 4 possible mechanisms.
