Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
PHARMACOLOGICAL STUDIES OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) REPORT 6: ANTIGENICITY AND RETICULOENDOTHELIAL STIMULATING EFFECT
Masako OkazakiTadashi KurimotoKeiko OzawaHitoshi Kato
Author information
JOURNAL FREE ACCESS

1979 Volume 39 Issue 6 Pages 637-642

Details
Abstract
Antigenicity of, NKK-105 and its solvent were studied with immunological procedures. Immunopharmacological tests in guinea pigs included active and passive anaphylaxis, passive cutaneous anaphylaxis, reversed passive Arthus reaction and Schultz-Dale reaction. NKK-105 and its solvent showed negative results on their antigenicity compared with positive ones of horse serum. Effect of NKK-105 and its solvent on reticuloendothelial system were studied by means of carbon clearance test. The solvent of NKK-105 showed reticuloendothelial stimulating effect and Zymosan as the reticuloendothelial stimulant showed stronger activity.
Content from these authors
© The Showa Medical Association
Previous article Next article
feedback
Top