THE EFFECTS OF A MINOR TRANQUILIZER ON TREATMENT OF SLEEP DISTURBANCE WITH ANXIETY BEFORE SURGERY “CLINICAL EVALUATION OF A NEW MINOR TRANQUILIZER, MEXAZOLAM (CS-386) BY A DOUBLE BLIND METHOD”

Abstract

Using the double blind method, Mexazolam (a new minor tranquilizer) and placebo were compared in 298 surgical patients. Three or five mg Mexazolam or the inert placebo were orally given to the patients, once a day, for 3 or 5 days before the surgical procedures. The following results were obtained :
1) Mexazolam exerted an anti-anxiety activity in the high or moderate anxiety group classified according to Manifest Anxiety Scale (MAS) .
2) Mexazolam was proved to have a very favorable effect on sleep disturbance by earlier falling asleep, better sleeping conditions, and less frequent awakening in the night.
3) Patients given 5 mg Mexazolam tended to show slightly more often unpleasant signs after treatment than those given the placebo. However, they was no significant difference in this respect on the patients given 3 mg Mexazolam.