Abstract
The authors recently examined a case of cryptococcal meningitis with simultaneous involvement of facial skin. A 73-year-old man was admitted to the Fujigaoka Hospital because of facial exanthema with headache followed by a fugue-like state. Cryptococcus neof ormans were isolated from the specimens of skin biopsy and CSF. Cases of this sort are relatively rare and cryptococcal meningitis, in most cases, begins with neurological symptoms such as meningeal signs, headaches and consciousness disorders followed by skin lesions. The combined therapy of Amphotericin B and 5-fluorocytosine was attempted and was remarkably beneficial in the eradication of clinical symptoms in this case and resulted in the disappearance of cryptococcus neoformans in CSF. Although the sugar value of CSF returned to the normal range at a relatively early stage, the number of cells and the protein value remained high until the subject's discharge. The sugar value was though to be the most useful index of improvement in the treatment for cryptococcal meningitis.
